When localized neuropathic pain persists and causes damage to the peripheral and central nervous system, the result can be a neuropathic pain disorder. The GABA receptors and the sites on nerve cells serve as the landing pad for certain chemicals and also are involved in the neuropathic pain for some people. GABA neurotransmitters act as a messenger in the brain, spinal cord, and peripheral nervous systems that allows nerve cells to communicate with each other. With this said, it pays to know more about GABA for neuropathic pain disorder.
GABA and Neurons
Gamma aminobutyric acid or also known as GABA is the chief inhibitory neurotransmitter of the brain and spinal cord. The effect of GABA is generally to inhibit or decrease the activity of neurons. GABA–B receptors serve as the landing port on the nerve cells that receives specific neurotransmitters. This could either excite or inhibit the nerve cell. There are two types of GABA receptors and these are located on certain neurons. The GABA-B receptors receive the GABA and also respond to mood stabilizer medicines. Examples of these mood stabilizers are lithium, carbamazepine, and valproate. The medication taken with GABA can inhibit neurons and decreasing the activity.
The GABA–A receptor, on the other hand, doesn’t only receive the GABA, but also binds with certain types of medications such as benzodiazepines, barbiturates, and neurosteroids. These medicines are usually used to treat anxiety, seizures, and suppress nervous system activity.
Nocioceptive pain is the one that alerts the brain and body to respond to and limit the damage caused to tissue. Neuropathic pain is a persistent pain and the result of a disease state. The myelin sheath is deteriorated in neuropathic pain. The sheath is the protective coating for the nerve. The growth of new receptor sites on nerve cells are responsible in responding to both incoming and outgoing messages to and from the brain and other pathological conditions and can cause chronic feedback loop of dysfunctional pain.
GABA for Neuropathic Pain Disorder
The enhancement of GABA in the central nervous system can help in the treatment of neuropathic pain by inhibiting nerve cell activity that perpetuates pain cycles. When activated by GABA and other medications, the GABA receptors on neurons on the dorsal horn of the spinal cord and the nerves in the amygdale, hypothalamus and other emotional modulation areas of the brain can reduce neuropathic pain when activated. Taking different medications can enhance GABA functions through different mechanisms. In doing so, it will appear to have varied positive effects on neuropathic pain. Some of the medications that can be used to treat neuropathic pain are tiagabine, gabapentin, benzoadiazepines, topiramate, valproate, and vigabatrin.
Neuropathic pain has a lot of causes, and may result from a wide spectrum of insults to the peripheral or central nervous system. This may include nutritional deficiency, systematic disease, chemoteraphy, surgery or trauma, and cerebrovascular accident. The cause of neuropathic pain is the abnormal neural activity in the peripheral nerve. This is associated by disordered sensory processing both in the peripheral or central nervous system. Injuries are considered peripheral in their location, and the central nervous often becomes involved. These may be solved by GABA supplements only when recommended by your doctor.